Medical Imaging

EPSRC Centre for Doctoral Training

Research

Projects

  • 105: Real-time imaging of ablation lesions during MRI-guided radiofrequency ablation of cardiac arrhythmias

    The aim of this project is to develop the next generation tools for advanced real-time monitoring of ablation lesions during magnetic resonance imaging (MRI)-guided radiofrequency ablation of cardiac arrhythmias. Specifically, this project will involve the development of novel MRI acquisition and reconstruction methods which will be evaluated in phantom experiments, healthy volunteers, and both pre-clinical and clinical studies. More...

  • 106 - High-resolution 3D diffusion MRI for body cancer diagnosis & evaluation

    The aim of this project is to develop a high-resolution 3D diffusion MRI acquisition method for accurate and robust diagnosis & therapy evaluation in body cancer. More...

  • 107: Endogenous Myocardial Fibrosis Assessment using T1rho MR Fingerprinting

    In this project we aim to develop, implement and test the clinical feasibility of a new efficient free-breathing Magnetic Resonance Fingerprinting (MRF) approach for accurate endogenous myocardial tissue characterisation. This approach will enable accurate and quantitative assessment of focal and diffuse myocardial fibrosis without the need of exogenous contrast agents and in a reduced scan time. More...

  • 108: Free-breathing assessment of myocardial fibrosis at a microstructural level using spin-echo cardiac diffusion tensor imaging

    The aim of the project is to develop a robust and reproducible free-breathing MRI technique for the assessment of the microstructure of replacement and diffuse fibrosis in the heart. More...

  • 109: Non-invasive imaging of cerebral oxygen metabolism in humans at ultra-high field

    The aims of this project are to: a)-To implement and refine a novel, non-invasive MRI method to generate high-resolution, whole brain maps of regional cerebral oxygen metabolism (CMRO2) using a new state-of-the-art, 7-Tesla human scanner. b)- To implement and test this new method, imaging methodology to obtain whole brain maps of regional cerebral blood flow (CBF) and voxel-wise Quantitative Susceptibility Mapping (QSM) will be adapted for use at 7-Tesla. c)- To use these measures to investigate functional metabolic changes that take place during rest and activation in healthy human subjects. More...

  • 111: 3D free-breathing high-resolution T1rho mapping and diffusion-prepared cardiac MRI for contrast-free myocardial tissue characterisation

    We aim to devise, implement and validate a 1) respiratory motion corrected (MC) 3D cardiac T1rho mapping sequence for contrast-free assessment of myocardial fibrosis and a 2) 3D cardiac diffusion-prepared sequence (trace apparent diffusion coefficient (trADC)) for assessment of myocardial microstructure by measuring the mean cardiac diffusivity. This approach will allow non-invasive quantification of myocardial fibrosis (collagen content) and mean cardiac diffusivity thereby providing insights into cardiac remodeling during infarct healing and in patients with different forms of cardiomyopthies. More...

  • 112: Development and Implementation of MRI compatible dual Cerenkov and fluorescence endoscope

    We propose to combine the advantages of widely-available MRI-based whole-body imaging with the promising emerging optical technique of fluorescence microendoscopy and Cerenkov luminescence. We plan to design and implement three detection modules to expand the clinical utility of microendoscopy, comprising wide-field video-rate fluorescence imaging, fluorescence spectrometry and Cerenkov luminescence point detection. These modules will allow sub-microns fluorophore detection, selectivity and quantification, together with the Cerenkov luminescence, an emerging technologie which allow the direct visualisation of a decay signal of a radioisotope. By complementing existing MRI technologies (e.g. structural, diffusion and perfusion MRI) with highly specific fluorescence imaging of endogenous autofluorescence and fluorescent markers (e.g. fluorescent tumour-targeting probes) and Cerenkov radiation, this novel multi-scale imaging platform will allow direct organ interrogation and optical biopsy, transiting the resolution boundaries. MR-guided fluorescence/Cerenkov microendoscopy has the potential to revolutionise the diagnosis, treatment and monitoring of a number of “difficult-to-access” deep tumours e.g. arising from the colon, prostate, and oesophagus. More...

  • 206: Molecular Imaging of Collagen in Cardiovascular Diseases

    This project will investigate the role of collagen deposition (fibrosis) in left ventricular (LV) remodeling and cardiac function post myocardial infarction (MI). We will also study the potential impact of therapies that aim at modulating the fibrotic response. The project will utilize a gadolinium-based collagen-biding MR contrast agent that is commercially available and is known to bind to collagen I fibers. In parallel, we will develop and evaluate gadolinium-based peptides that selectively bind to collagen types I or III and which allow discrimination of the different types of collagen and thus enhance our understanding of collagen turnover in disease progression. In vivo MRI experiments will be complemented by ex vivo analysis. Finally, we will investigate if steady state collagen imaging could be an alternative to first pass perfusion imaging thereby allowing for higher spatial resolution and use of exercise stress protocols outside of the MR scanner. More...

  • 208: Core/shell and ‘alloy’ organic semiconductor nanoparticles for multimodal imaging

    The project aims to prepare conjugated polymer nanoparticles with novel structures (core/shell and alloys/blendes) to enhance the optical properties for medical imaging. We will also include a surfactant which allows the coordination of a radionuclide to the particle resulting in an optical/PET multimodal imaging agent. More...

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