Medical Imaging

EPSRC Centre for Doctoral Training

Research

Projects

  • 100: Advanced cardiac magnetic resonance perfusion imaging

    The aim of this project is to develop the next generation tools for advanced cardiovascular magnetic resonance (CMR) perfusion imaging. Novel CMR imaging sequences will be designed and implemented for both qualitative and quantitative perfusion imaging. This work will also involves the development of novel quantitative CMR reconstruction techniques. These new methods will be validated using our unique perfusion phantom and in patients. More...

  • 102 - 3D Free-breathing high-resolution T1rho-mapping and diffusion-prepared cardiovascular MRI for contrast-free myocardial tissue characterization

    Myocardial tissue injury and inflammation often heals with diffuse and/or replacement fibrosis, Regardless of the aetiology, fibrosis increases the risk of arrhythmias and heart failure. Late gadolinium enhancement (LGE) and T1-mapping have become the preferred imaging techniques to assess infarct size and quantify extracellular volume (ECV), a surrogate for diffuse fibrosis. More...

  • 103 - Multidimensional and Multiparametric Quantitative Cardiac MRI from Continuous Free-Breathing Acquisition

    Magnetic Resonance Imaging (MRI) has become an increasingly important non-invasive tool for risk assessment and treatment monitoring of cardiovascular disease. In comparison to alternative imaging modalities (e.g. echocardiography, X-ray fluoroscopy, computed tomography and positron emission tomography) MRI has the advantage of combining excellent soft tissue characterization with high spatial resolution, and does not require ionizing radiation. Cardiac MRI has been established as a clinically important technique for the assessment of cardiac morphology, function (CINE MRI), perfusion (MR-perfusion) and viability (LGE, infarct). More...

  • 104 - A Simultaneous Multicontrast PET-MR Sequence for Comprehensive Coronary Plaque Characterization

    Acute myocardial infarction (AMI) is a leading cause of death worldwide. AMI is predominantly caused by rupture or erosion of high-risk plaque leading to thrombus formation and sudden occlusion of the coronary arteries. The current strategy for managing patients at high risk of myocardial infarction, based on invasive tests and population-derived risk factors, fails to predict up to 50% of acute coronary events. More...

  • 105 - A machine learning approach to solving the SAR problem for ultrahigh field MRI

    Ultrahigh field (UHF) MRI has the potential to provide very high resolution anatomical images with new types of contrast compared with more conventional lower field MRI. However the required high-frequency RF fields are highly spatially variable inside the human body, and in order to image outside the brain multiple transmitters (so called parallel transmit, pTx) are required1. An issue with this approach is that quantification of potential RF heating effects is not straightforward. Currently UHF-MRI facilities use conservative safety limits that ensure safety but stop UHF-MRI from reaching its true potential. UHF-MRI also often requires specialist operators, limiting workflow and clinical applicability. More...

  • 106 - Multiparametric low-dose PET-MR for single-scan diagnostic imaging of memory clinic patients

    Dementia has been recognised as a major public health problem worldwide, with a prevalence of around 6.5% in the over-65s in England (e.g. Matthews F et al. Lancet 2013). Assessment at memory clinics includes clinical and cognitive assessment and structural imaging with MRI as standard. Among the additional tests (e.g. DAT SPECT, amyloid PET), FDG PET is probably the most versatile, able to provide differential diagnostic information and an indication of the degree of severity of abnormalities, but is often used late in the patient pathway. More...

  • 107 - Modality propagation and machine learning for detection of the epileptogenic zone from [18F]FDG PET and MR imaging

    Epilepsy is one of the commonest neurological disorders, affecting about 1 in 200 people in developed countries. Anti-epilepsy drugs only eliminate seizures in about two thirds of patients. Epilepsies can be generalised, starting from the whole brain essentially simultaneously, or focal, starting from one focus (the “epileptogenic zone”, EZ). In focal epilepsies, removal of the EZ can lead to long-term seizures-freedom. A prerequisite is the precise identification of the EZ. More...

  • 108 - Quantitative MRI of the fetus

    Fetal MRI has been established in clinical practice for investigation of pathology, and more recently in research into brain development. As the fetus develops the brain undergoes dramatic morphological and microstructural changes, that can be visualised using MRI (see Fig. 1). During the second half of pregnancy important developmental processes take place, in particular neuronal migration, formation of white matter tracts, beginnings of myelination and appearance of cortical folds. These changes can be observed on standard MR images, both as changes in morphology (folding for example) or the change of apparent contrast. Contrast is determined both by the underlying tissue properties (T1, T2, T2*, …) and the properties of the imaging sequence. More...

  • 110 - Investigating brain development in neonates using ultrahigh field MRI

    Ultrahigh field (UHF) MRI (>=7T) offers increased sensitivity and research has shown significant potential improvements in data quality for a number of applications in adults. We aim to pioneer the investigation of brain development in normal and ex-preterm infants using UHF MRI, exploring differences in T1 and T2 values and taking advantage of the enhanced T2* weighted contrast using very high resolution to visualise small developing structures. More...

  • 112 - Advanced real-time MRI-guided cardiac catheterization

    More than 0.5% of new born babies have congenital heart disease (CHD) [1]. Cardiac catheterisation is a common diagnostic and interventional procedure in patients with CHD, especially in planning palliative or corrective surgical procedures [2]. This procedure is performed under X-ray guidance, which is associated with poor soft tissue visualisation which complicates the positioning of catheters, balloons, and interventional device. Furthermore, X-ray doses used during this procedure are associated with increased risks for cancer [3]. More...

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