Medical Imaging

EPSRC Centre for Doctoral Training

Research

Projects

  • 118 - Passive Imaging of Acoustic Sources: Novel imaging algorithms for monitoring therapeutic ultrasound

    Acoustic sources are objects that emit sound, such as a car, a dolphin, and underground rivers. Sound emitted from these sources can be captured to identify them or characterise their behaviours. Acoustic detection is unique, because it can describe objects through opaque material. One limitation with acoustic detection methods was that they are unable to locate – with good precision – where the sound is coming from. More...

  • 212 - New Lipophilic Cations for Imaging Apoptosis and the Mitochondria

    Apoptosis is the most common form of programmed cell death and is a key mechanism in many pathological diseases. These include cancer, diabetes, neurodegenerative disorders and aging. Being able to fully understand this mechanism could lead to huge advances in detection, drug development and treatment. Currently there are very few non-invasive techniques capable of quantifying and assessing the process of apoptosis in humans. The discovery that mitochondria play an important role in the early stages of apoptosis has directed focus to targeting the mitochondria as a means of identifying disease. Changes in mitochondrial membrane potential (m) can be directly related to mitochondrial dysfunction, representing a biophysical process that could be targeted with imaging. More...

  • 307 - Development of a decision support tool for neuroimaging using explainable ML

    The purpose of this project is to develop an ML-based decision support tool for brain Magnetic Resonance Images (MRI) with application to neurological disorders. A particular focus will be on the development of a decision support tool that will not only be able to diagnose patients based on clinical imaging and non-imaging information, but will also be able explain how it has reached its decision. For this, we will use a large database of multi-modal brain MRI from patients with different forms of dementia. More...