Smart Medical Imaging

EPSRC Centre for Doctoral Training

Research

Projects

  • 2019_029 - Motion-robust metabolite quantification in the fetal brain with MR spectroscopy

    Measuring metabolite concentration in the fetal brain with MR Spectroscopy (MRS) has potential to assess the effects of placental dysfunction or alterations in the fetal circulation from congenital heart disease on brain development. However, due to continuous/unpredictable fetal motion, with standard MRS methodology, current success rate is ~50%. We aim to develop a motion-robust MRS method resilient to fetal motion. This will be based on 3D volume navigator images collected concurrently with each MRS acquisition (every ~2 seconds), and fast real-time feedback allowing adjustment of the VOI position to maintain it in the same anatomical position irrespective of motion. Monitoring extent of motion and data similarity between repeats will allow quality assessment of the cumulative data collected and extension of the acquisition until data of sufficient signal-to-noise ratio for meaningful analysis has been collected. The aim is for fetal MRS to become a usable, reliable and robust clinical investigation tool. More...