Medical Imaging

EPSRC Centre for Doctoral Training


Current Projects

  • Jorge Mariscal-Harana

    Non-invasive proximal blood pressure estimation by combining MR imaging with one­‐dimensional flow modelling

    Jorge Mariscal-Harana - 2015 entry

    This project will further develop our existing one-dimensional (1-D) model of blood flow in the arterial tree to facilitate its use for patient-specific medical planning. We will create a user-friendly workflow within the open-source Nektar++ framework ( to calculate blood pressure (BP) waveforms in the larger arteries of the systemic or pulmonary circulations from patient-specific data that can be measured noninvasively in the clinic using magnetic resonance imaging. Applanation tonometry will also be used for the systemic circulation. Moreover, we will develop post-processing tools to identify the physical mechanisms underlying calculated BP waveforms by separating contributions from the heart, buffering function of the aorta or larger pulmonary arteries, and proximal and peripheral wave reflections. This project will provide a software package for rapid and accurate patient-specific BP modelling and analysis that will run on Linux, Mac and Windows platforms at a much smaller computational cost than 3-D modelling. More...

  • Sophie Morse

    Noninvasive Molecular Biopsy – Focused Ultrasound Delivery of Targeted Contrast Agents and Detection by Magnetic Resonance Imaging

    Sophie Morse - 2015 entry

    The overarching aim of the project is to develop a noninvasive biopsy system that can image the molecular signatures of a disease in its in vivo native state, in 3D, and throughout the progression of the disease. A focused ultrasound-based drug delivery system will be used to noninvasively and locally deliver normally impermeable targeted MRI contrast agents across the capillaries of a target disease (such as breast cancer). MRI pulse sequences will then be optimised to detect the bound targeted MRI contrast agents in vivo from the surrounding tissue and unbound contrast agents. The sub-aims of this project are (1) to design ultrasound parameters for delivering targeted MRI contrast agents, (2) to identify and/or design targeted MRI contrast agents that could provide sufficient signal contrast when delivered by ultrasound, and (3) to optimise MRI pulse sequences to identify bound targeted contrast agents. More...

  • Rainbow Lo

    Novel theranostic targeted anti-cancer probe for multi-modal imaging on multiple scales

    Rainbow Lo - 2015 entry

    In this project we will develop cancer cell-targeted theranostic compounds for visualizing tumours at a whole-body (using SPECT/PET) and microscopic (using optical imaging) level; at the same time the compound stabilizes guanine-rich DNA/RNA structures (G-quadruplexes) that are inhibitory to cancer cell proliferation and oncogene expression. The probes will be built by coupling a known platinum-based cytotoxic agent (which also acts as an optical probe) and the radioisotope chelator DOTA to a peptide or antibody that selectively targets cancer cells. We will also aim to modify the platinum-based cytotoxic agent such that it is only activated in the reducing environment found within targeted cells thereby reducing potential off-target activity risks. In this way, our theranostic agent will be highly selective against cancer cells and allow tracking the tumour uptake of the cytotoxic probe on a whole-body level as well as visualize targeted cells on a microscopic level. More...

  • James Bland

    Sparse and synergistic multi‐parametric PET‐MR image reconstruction for imaging brain disorders

    James Bland - 2015 entry

    In the context of the recent arrival of simultaneous PET‐MR imaging, this project seeks to advance the field of image reconstruction for PET‐MR imaging by bringing together the progress made separately for PET and MR reconstruction, combining them into a unified PET‐MR image reconstruction framework. This will involve direct parametric reconstruction from raw PET data as well as direct parametric image reconstruction from simultaneously acquired MR k‐space data. The concept of sparsity will be exploited in both the PET and MR functional parametric map reconstructions, as a means of limiting noise, in addition to exploiting correlations between PET and MR parameters. The overall aim is to achieve a reconstruction for each modality which surpasses that obtainable from each modality in isolation. The initial focus of application will be for the imaging of brain disorders, where issues such as subject movement are easier to deal with than for imaging of the body. More...

  • Jemma Brown

    Super Resolution Ultrasound Imaging

    Jemma Brown - 2015 entry

    In this project techniques to increase the spatial resolution, sensitivity and image acquisition speed of super-resolved ultrasound images will be investigated. New adaptive data acquisition strategies and post-acquisition signal processing techniques will be investigated. In particular the project will investigate how recent developments in super-fast ultrasound imaging could be used to provide 3D super-resolved ultrasound imaging at resolutions far beyond the conventional diffraction limit. More...

  • Karina Lopez

    Tissue Characterisation for the Management of Cardiac Arrhythmia

    Karina Lopez - 2015 entry

    The aim of this project is to develop novel quantitative MR techniques to characterize cardiac tissue for the management of cardiac arrhythmias. This project has a particular focus on driving the innovation that underpins an interventional MRI electrophysiology program, and these techniques can be divided into three main areas of arrhythmia management. Firstly, techniques will be developed for the assessment of the arrhythmia substrate within the atria and ventricles, guiding risk stratification and intervention planning. This will include substrate analysis for ventricular tachycardia (VT) and atrial fibrosis assessment, including fibrosis/scar quantification and wall thickness. Secondly, techniques will be developed for the live guidance of ablation procedures. Hyperacute (during radiofrequency (RF) energy delivery) and acute (within 60 min of RF delivery) techniques will include T1 mapping (3D and 2D), diffusion weighted imaging, T2 weighted imaging and gadolinium enhanced imaging (early and late). Thirdly, imaging techniques of the effect and quantification of ablation will be optimised, building upon a 3D LGE technique. More...

  • Jed Wingrove

    An imaging investigation of the central effects of insulin via intra-nasal administration

    Jed Wingrove - 2014 entry

    The aims are to: 1. Study the central effects of intra-nasal insulin administration (IN-Ins) on regional Cerebral Blood Flow (rCBF) and brain activity. This will be done using contemporary Arterial Spin Labelling (ASL) and functional Magnetic Resonance Imaging (fMRI) methods in young, healthy volunteers. 2- Study the effects of IN-InS on pre- and post-prandrial responses in both healthy and in obese, Insulin Resistant (IR), non-diabetic subjects using functional ASL and fMRI 3- Evaluate the effects of IN-InS on executive function, affective processing and memory using a battery of cognitive tests. More...

  • Jennifer Young

    Bifunctional chelator design for rapid in vitro and in vivo labelling of targeting biomolecules with short half life radiometals

    Jennifer Young - 2014 entry

    The advent an imminent marketing authorisation of the gallium-68 generator presents great scope for development of applications of this short half life isotope in PET imaging. Fast,simple methods to incorporate short half life radiometals such as Ga-68 and Bi-213 into radiopharmaceuticals are required to facilitate clinical application on a wide scale - labelling must be quick and simple, under mild conditions and yielding high specific activity with extremely low amounts of biomolecules (eg 10 microgram). This is a challenge for chelator design, because features of chelators that promote in vivo kinetic stability (required to ensure that the biomolecule keeps its label in vivo for long enough to perform the scan), such as macrocyclic structure, impose high kinetic barriers to labelling making labelling slow or requiring harsh conditions. More...

  • Adela Capilnasiu

    Fighting fibrosis: a complementary biomechanical approach to characterize and distinguish fibrosis from inflammation in chronic diseases of the liver and heart

    Adela Capilnasiu - 2014 entry

    Aim of this PhD project is: 1. to develop a comprehensive package for the assessment of biomechanical information (MR-elastography sequence development and reconstruction of biomechanical information using non-linear elasticity and finite element techniques), 2. to perform clinical studies on patients with liver fibrosis/inflammation and heart diseases (in particular patients with normal ejection fraction), and 3. to correlate the biomechanical information to detailed histology, molecular profiles, and PET-MR metrics. More...

  • Giovanna Nordio

    High-resolution whole-heart parameter mapping using image-based respiratory navigation and compressed sensing.

    Giovanna Nordio - 2014 entry

    To develop image-based respiratory motion corrected parameter mapping in conjunction with compressed sensing image acceleration methods. This will enable the use of motion corrected whole-heart T1 and T2 mapping with high spatial resolution in a clinically feasible scan time. Such parameter mapping techniques may be clinically valuable tools for the detection of myocardial fibrosis and oedema as well as for coronary plaque characterization. More...

Previous 12345678 Next