Student: Megan Midson
1st supervisor: Mark Green, King’s College London
2nd supervisor: Nick Long, Imperial College London
3rd supervisor: Rafael T.M. de Rosales, King’s College London
4th supervisor: Phil Blower, King’s College London
In this multidisciplinary, cross-college project, we will prepare MFe2O4/BaYbF5;X,Y core/shell materials (M = Co, Mn; X, Y, = Eu, Tm, Yb, Er, Ho, Tb) using organometallic chemistry developed in the research groups of Long and Green. We will then utilise a range of bisphosphonate ligands, developed by the Long/Torres groups to induce hydrophilicity whilst providing anchoring points for further radionuclides. In this manner, the ferrite core will provide MRI activity, the BaYbF5 shell will provide the CT functionality whilst the dopant rare-earth ions provide the optical emission. Numerous groups can be engineered into the ligands, including anchors for radionuclides (for PET/SPECT imaging) and further functional groups for the coordination of peptides, antibodies, etc.
The resulting multimodal particles will be evaluated preclinically in a wide range of imaging systems, including (i) initial cell tracking experiments using established mouse models in which conventional methods of cell tracking are established, jointly with the Blower group, (ii) mouse models of atherosclerotic plaque (collaboration with Botnar, KCL), (iii) pancreatic inflammation (collaboration with Peakman, KCL) and (iv) in breast cancer models (collaboration with Aboagye, ICL)